April 6, 2015

Glycerin—produced by hydrolysis of fats and oils – getfile

Glycerin—produced by hydrolysis of fats and oils – getfile.

A 2-year study, established the overall “no observable effects limit (NOEL)” after prolonged 613 treatment with glycerin of 10,000 mg/kg body weight (20% in diet), which is in agreement with the 614 findings in other studies. At this dose level, no systemic or local effects were observed. For inhalation exposure to aerosols, there is evidence of local irritant effects at and above 662 mg/m3 . The no observable adverse effects (NOAEL) limit is 167 mg/

Glycerin does not induce gene mutations in bacterial strains, chromosomal effects in mammalian cells or primary DNA damage in vitro. Results seen in a limited mammalian gene mutations test were of uncertain biological relevance. In vivo, glycerin produced no statistically significant effect in a chromosome aberrations and dominant lethal study. However, the limited details provided and absence of a positive control prevent any reliable conclusions can be drawn from the in vivo data. Overall, glycerin is not considered to possess genotoxic potential.

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