Abstract provisionalBackgroundElectronic cigarettes have been developed and marketed in recent years as smoking substitutes. However, no studies have evaluated their effects on the cardiovascular system. The purpose of this study was to examine the immediate effects of electronic cigarette use on left ventricular LV function, compared to the well-documented acute adverse effects of smoking.MethodsEchocardiographic examinations were performed in 36 healthy heavy smokers SM, age 36 +/- 5 years before and after smoking 1 cigarette and in 40 electronic cigarette users ECIG, age 35 +/- 5 years before and after using the device with “medium-strength” nicotine concentration 11 mg/ml for 7 minutes. Mitral flow diastolic velocities E, A, their ratio E/A, deceleration time DT, isovolumetric relaxation time IVRT and corrected-to-heart rate IVRT IVRTc were measured. Mitral annulus systolic Sm, and diastolic Em, Am velocities were estimated. Myocardial performance index was calculated from Doppler flow MPI and tissue Doppler MPIt. Longitudinal deformation measurements of global strain GS, systolic SRs and diastolic SRe, SRa strain rate were also performed.ResultsBaseline measurements were similar in both groups. In SM, IVRT and IVRTc were prolonged, Em and SRe were decreased, and both MPI and MPIt were elevated after smoking. In ECIG, no differences were observed after device use. Comparing after-use measurements, ECIG had higher Em P = 0.032 and SRe P = 0.022, and lower IVRTc P = 0.011, MPI P = 0.001 and MPIt P = 0.019. The observed differences were significant even after adjusting for changes in heart rate and blood pressure.ConclusionsAlthough acute smoking causes a delay in myocardial relaxation, electronic cigarette use has no immediate effects. Electronic cigarettes’ role in tobacco harm reduction should be studied intensively in order to determine whether switching to electronic cigarette use may have long-term beneficial effects on smokers’ health.Trial registration: Current Controlled Trials ISRCTN16974547The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.
via BMC Cardiovascular Disorders | Abstract | Acute effects of using an electronic nicotine-delivery device electronic cigarette on myocardial function: comparison with the effects of regular cigarettes.