Data on nicotine absorption are scarce. Initially, EC use commonly called vaping was found to deliver minimal amounts of nicotine to the user as measured by plasma nicotine levels8, 9. However, there has been a fast evolution of new, more efficient devices, and devices used at the time of those experiments are currently outdated and off the market. Surveys have shown that new-generation devices are more popular in dedicated EC users and a significant proportion of these users report complete smoking cessation10, 11. However, no study has evaluated nicotine absorption from such devices. Therefore, the purpose of this study was to compare the nicotine absorption from a first- vs. a new-generation device in experienced vapers.